This book constitutes the joint refereed proceedings of the 10th International Conference on Artificial Intelligence and Symbolic Computation, AISC 2010, the 17th Symposium on the Integration of Symbolic Computation and Mechanized Reasoning, Calculemus 2010, and the 9th International Conference on Mathematical Knowledge Management, MKM 2010.All submissions passed through a rigorous review process. From the 25 papers submitted to AISC 2010, 9 were selected for presentation at the conference and inclusion in the proceedings volume. A total of 14 papers were submitted to Calculemus, of which 7 were accepted. MKM 2010 received 27 submissions, of which 16 were accepted for presentation and publication.The events focused on the use of AI techniques within symbolic computation and the application of symbolic computation to AI problem solving; the combination of computer algebra systems and automated deduction systems; and mathematical knowledge management, respectively.