This book constitutes the refereed proceedings of the 5th InternationalConference on Global Perspectives on Design Science Research, DERIST2010, held in St. Gallen, Switzerland, in June 2010.The 35 revised full papers presented together with 10 revised shortpapers were carefully reviewed and selected from 80 submissions. Thepapers are organized in topical sections on organising design research, reflecting design science research, design research techniques, designand context, design and organisation, design and information, designresearch exemplars, design and behaviour, designing collaboration, aswell as design and requirements engineering.