This book constitutes the refereed proceedings of the 6th InternationalConference on Information Systems Security, ICISS 2010, held inGandhinagar, India, in December 2010.The 14 revised full papers presented together with 4 invited talks werecarefully reviewed and selected from 51 initial submissions. The papersare organized in topical sections on integrity and verifiability, weband data security, access control and auditing, as well as systemsecurity.