Volumes CCIS 107 and LNCS 6382 constitute the proceedings of the 5th International Symposium, ISICA 2010, held in Wuhan, China, in October 2010.ISICA 2010 attracted 267 submissions and through rigorous reviews 53 papers were included in LNCS 6382.The papers are presented in sections on ANT colony and particle swarm optimization, differential evolution, distributed computing, genetic algorithms, multi-agent systems, multi-objective and dynamic optimization, robot intelligence, statistic learning and system design.