This book contains selected papers from the e-Commerce and e-Business (SIGeBIZ) track at the 16th Americas Conference on Information Systems, AMCIS 2010, held in Lima, Peru, August 12-15, 2010.The 13 papers presented here were selected from 48 submissions and have been organized into three research lines: e-business models and information systems in financial markets, e-commerce use and design, and e-business research issues and methods.