This book constitutes the refereed proceedings of the 6th International Conference, ICGS3, held in Braga, Portugal, in September 2010.The 31 revised full papers presented together with 3 keynote papers were carefully reviewed and selected from many submissions. The topics are divided into six streams: e-S3, Physical S3, S3 Strategic Frameworks, Cybernetic S3, Socio- Technical Systems as well as Emerging Trends.