This book constitutes the refereed proceedings of the 10th International Conference on Next Generation Teletraffic and Wired/Wireless Advanced Networking, NEW2AN 2010, held in conjunction with the Third Conference on Smart Spaces, ruSMART 2009 in St. Petersburg, Russia, in August 2010.The 27 revised NEW2AN full papers are organized in topical sections on performance evaluation; performance modeling; delay-/disruption-tolerant networking and overlay systems; integrated wireless networks; resource management; and multimedia communications. The 14 revised ruSMART full papers are about smart spaces use cases; smart-M3 platform; and smart spaces solutions.