This book constitutes the refereed proceedings of the 11th International Conference on Parallel Problem Solving from Nature - PPSN XI, held in Krak w, Poland, in September 2010. The 131 revised full papers were carefully reviewed and selected from 232 submissions. The conference covers a wide range of topics, from evolutionary computation to swarm intelligence, from bio-inspired computing to real world applications. Machine learning and mathematical games supported by evolutionary algorithms as well as memetic, agent-oriented systems are also represented.