This book constitutes the refereed proceedings of the 14th East European Conference on Advances in Databases and Information Systems, ADBIS 2010, held in Novi Sad, Serbia on September 20-24, 2010. The 36 revised full papers and 14 short papers were carefully selected from 165 submissions. Tolically the papers span a wide spectrum of topics in the database and information systems field, including database theory, advanced DBMS technologies, design methods, data mining and data warehousing, spatio-temporal and graph structured data and database applications.