This book constitutes the refereed proceedings of the 16th International Euro-Par Conference held in Ischia, Italy, in August/September 2010.The 90 revised full papers presented were carefully reviewed and selected from 256 submissions. The papers are organized in topical sections on support tools and environments; performance prediction and evaluation; scheduling and load-balancing; high performance architectures and compilers; parallel and distributed data management; grid, cluster and cloud computing; peer to peer computing; distributed systems and algorithms; parallel and distributed programming; parallel numerical algorithms; multicore and manycore programming; theory and algorithms for parallel computation; high performance networks; and mobile and ubiquitous computing.