This book constitutes the refereed proceedings of the 10th InternationalWorkshop on Digital Mammography, IWDM 2010, held in Girona, Spain, inJune 2010. The 46 revised full papers and 57 revised poster papers presented werecarefully reviewed and selected from 141 initial submissions. The papersare organized in topical sections on CAD, image processing and analysis, breast imaging physics, physics models, clinical experiences, breastdensity, digital breast tomosynthesis, lesion detection, andregistration.